Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl.

ABSTRACT:

Background

Working dogs exposed to narcotics might require reversal in the field.

Objective

To explore the pharmacokinetic and pharmacodynamic effects of naloxone administered intramuscularly (IM) or intranasally (IN) to reverse fentanyl sedation in working dogs.

Animals

Ten healthy, working dogs aged 1.7 ± 1 year and weighing 26 ± 3 kg.

Methods

In this randomized, controlled cross-over study dogs received either 4 mg of naloxone IN or IM 10 minutes after fentanyl (0.3 mg IV) administration. Sedation was assessed at baseline and 5 minutes after fentanyl administration, then at 5, 10, 15, 20, 25, 30, 60 and 120 minutes after reversal with naloxone. Blood samples for naloxone detection were obtained at 0, 5, 10, 30, 60 and 120 minutes. Pharmacokinetic parameters

SUBMITTER: Barr CA 

PROVIDER: S-EPMC10658493 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature