Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses.

ABSTRACT:

Background

Treatment with phenylbutazone (nonselective COX inhibitor) decreases the diuretic and natriuretic effects of furosemide by nearly 30% but the effects of COX-2 specific inhibitors (firocoxib) and atypical NSAIDs (dipyrone) are unknown.

Hypothesis

Furosemide-induced diuresis after pretreatment with firocoxib or dipyrone is diminished to a lesser extent than after pretreatment with phenylbutazone.

Animals

Eight healthy mares.

Methods

Each mare received 4 treatments in a prospective experimental crossover study using a replicated 4 × 4 Latin Square design: furosemide alone (FU), furosemide and phenylbutazone (PB), furosemide and firocoxib (FX), and furosemide and dipyrone (DP). After 24 hours of NSAID treatment at recommended dosages, ureteral catheters

SUBMITTER: White JM 

PROVIDER: S-EPMC10658499 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature