Oral cytarabine ocfosfate pharmacokinetics and assessment of leukocyte biomarkers in normal dogs.

ABSTRACT:

Background

Cytosine arabinoside (Ara-C) is a nucleoside analog prodrug utilized for immunomodulatory effects mediated by its active metabolite Ara-CTP. Optimal dosing protocols for immunomodulation in dogs have not been defined. Cytarabine ocfosfate (CO) is a lipophilic prodrug of Ara-C that can be administered PO and provides prolonged serum concentrations of Ara-C.

Objectives

Provide pharmacokinetic data for orally administered CO and determine accumulation and functional consequences of Ara-CTP within peripheral blood leukocytes.

Animals

Three healthy female hound dogs and 1 healthy male Beagle.

Methods

Prospective study. Dogs received 200 mg/m² of CO PO q24h for 7 doses. Serum and cerebrospinal fluid (CSF) CO and Ara-C concentrations were measure

SUBMITTER: Zwueste DM 

PROVIDER: S-EPMC10658504 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature