Individualized chemotherapy drug dose escalation in dogs with multicentric lymphoma.

ABSTRACT:

Background

This study was performed to determine the ability to escalate drug doses in a 15-week CHOP protocol in dogs with multicentric lymphoma.

Hypothesis

We hypothesized that at least 50% of dogs could successfully be escalated in at least 1 drug. Secondary aims were to establish objective response rate (ORR), progression-free interval (PFI), and overall survival time (OST).

Animals

Thirty dogs with newly diagnosed multicentric lymphoma were prospectively treated with a 15-week CHOP protocol.

Methods

This was a prospective cohort study. Drug doses that did not cause dose-limiting adverse effects (AEs) were increased using a standardized escalation protocol. AEs and response were assessed using VCOG criteria. Serial blood samples were collected after the fir

SUBMITTER: Siewert JM 

PROVIDER: S-EPMC10658528 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature