MOCOS-associated renal syndrome in a Brown Swiss cattle.

ABSTRACT:

Background

A recessive form of MOCOS-associated xanthinuria type II is described in Tyrolean grey cattle. A similar case was identified in a 5-month-old Brown Swiss calf with hoof overgrowth, rough coat, urine sediment, and pneumonia.

Hypothesis/objectives

To characterize the disease phenotype, to evaluate its genetic etiology, and to determine the prevalence of the deleterious allele in the Brown Swiss population.

Animals

An affected calf, its parents, and 65 441 Swiss dairy cattle.

Methods

The affected animal was clinically examined and necropsied. Microarray genotyping was used to determine the genotypes and to assess the frequency of the MOCOS allele in a Brown Swiss control cohort.

Results

Ultrasonography revealed hyperechoic renal pyramids with mul

SUBMITTER: Jacinto JGP 

PROVIDER: S-EPMC10658536 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature