Adeno-associated virus-vectored erythropoietin gene therapy for anemia in cats with chronic kidney disease.

ABSTRACT:

Background

A treatment of chronic kidney disease (CKD)-associated anemia in cats is needed. SB-001 is an adeno-associated virus-vectored (AAV)-based gene therapeutic agent that is administered intramuscularly, causing the expression of feline erythropoietin.

Hypothesis/objective

We hypothesized that SB-001 injection would lead to a sustained increase in PCV in cats with CKD-associated anemia.

Animals

Twenty-three cats with International Renal Interest Society (IRIS) Stage 2 to 4 CKD-associated anemia were enrolled at 4 veterinary clinics.

Methods

In a prospective clinical trial, cats were treated with 1 of 3 regimens of SB-001 (Lo 1.2 × 10⁹ genome copies [GCs] on Day 0; Lo ± Hi [supplemental 2nd dose of 3.65 × 10⁹ GC on Day 42]; Hi 3.65 × 

SUBMITTER: Vaden SL 

PROVIDER: S-EPMC10658539 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature