Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function.

ABSTRACT:

Background

It is unknown if enrofloxacin accumulates in plasma of cats with reduced kidney function.

Hypothesis

To determine if enrofloxacin and its active metabolite ciprofloxacin have reduced clearance in azotemic cats.

Animals

Thirty-four cats hospitalized for clinical illness with variable degree of kidney function.

Methods

Prospective study. After enrofloxacin (dose 5 mg/kg) administration to cats, sparse blood sampling was used to obtain 2 compartment population pharmacokinetic results using nonlinear mixed-effects modeling. Plasma enrofloxacin and ciprofloxacin concentrations were measured and summed to obtain the total fluoroquinolone concentration. A model of ciprofloxacin metabolism from enrofloxacin was created and evaluated for covariate effects on

SUBMITTER: Foster JD 

PROVIDER: S-EPMC10658592 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature