Novel genomic prognostic biomarkers for dogs with cancer.

ABSTRACT:

Background

Growing evidence from dogs and humans supports the abundance of mutation-based biomarkers in tumors of dogs. Increasing the use of clinical genomic diagnostic testing now provides another powerful data source for biomarker discovery.

Hypothesis

Analyzed clinical outcomes in dogs with cancer profiled using SearchLight DNA, a cancer gene panel for dogs, to identify mutations with prognostic value.

Animals

A total of 127 cases of cancer in dogs were analyzed using SearchLight DNA and for which clinical outcome information was available.

Methods

Clinical data points were collected by medical record review. Variables including mutated genes, mutations, signalment, and treatment were fitted using Cox proportional hazard models to identify factors associate

SUBMITTER: Chon E 

PROVIDER: S-EPMC10658597 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature