Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study.

ABSTRACT:

Objective

Observational studies have reported bidirectional associations between metabolic syndrome (MetS) traits and short leukocyte telomere length (LTL), a TL marker in somatic tissues and a proposed risk factor for age-related degenerative diseases. However, in Mendelian randomization studies, longer LTL has been paradoxically associated with higher MetS risk. This study investigated the hypothesis that shorter LTL might be a consequence of metabolic dysfunction.

Methods

This study undertook univariable and multivariable Mendelian randomization. As instrumental variables for MetS traits, all of the genome-wide significant independent signals identified in genome-wide association studies for anthropometric, glycemic, lipid, and blood pressure traits conducted in European

SUBMITTER: Loh NY 

PROVIDER: S-EPMC10658743 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature