FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear.

Methods

Herein, we analyzed the expression level of FTH1 in HNSCC using TCGA database, and FTH1 protein in HNSCC tissues and cell lines was determined by immunohistochemistry (IHC) and western blotting, respectively. Then, its prognostic value and relationship with clinical parameters were investigated in HNSCC patients. Additionally, the biological function of FTH1 in HNSCC was explored.

Results

The current study showed that FTH1 is significantly overexpressed in HNSCC tissues and related to poor prognosis and lymph node me

SUBMITTER: Liao Q 

PROVIDER: S-EPMC10658887 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature