TMUB1 expression is associated with the prognosis of colon cancer and immune cell infiltration.

ABSTRACT:

Background

TMUB1 is a transmembrane protein involved in biological signaling and plays an important role in the stability and transcription of P53. However, its role in tumor remains unknown.

Methods

Using R language, the expression level of 33 cancer spectrum TMUB1 was analyzed by the public database TCGA, GEO and HPA, the differential expressed gene (DEG) screening and protein interaction (PPI) network was constructed, and the differential genes of TMUB1 in colon cancer were identified. The relevant signaling pathways were identified by gene functional annotation and enrichment analysis. The ssGSEA algorithm in GSVA were used for immune infiltration analysis. The Kaplan-Meier analysis, univariate and multivariate Cox regression analysis, nomogram and c

SUBMITTER: Lu Y 

PROVIDER: S-EPMC10658890 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature