Ontology highlight
ABSTRACT:
SUBMITTER: Zheleva A
PROVIDER: S-EPMC10658913 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Zheleva Angelina A Camino Lola P LP Fernández-Fernández Nuria N García-Rubio María M Askjaer Peter P García-Muse Tatiana T Aguilera Andrés A
Journal of cell science 20211022 20
Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is a conserved eukaryotic protein complex with a key role in mRNP biogenesis and maturation that prevents genome instability. One source of such instability is linked to transcription, as shown in yeast and human cells, but the underlying mechanism and whether this link is universal is still unclear. To obtain further insight into the putative role of the THSC/TREX-2 complex in g ...[more]