Placental inflammatory cytokines mRNA expression and preschool children's cognitive performance: a birth cohort study in China.

ABSTRACT:

Background

The immunologic milieu at the maternal-fetal interface has profound effects on propelling the development of the fetal brain. However, accessible epidemiological studies concerning the association between placental inflammatory cytokines and the intellectual development of offspring in humans are limited. Therefore, we explored the possible link between mRNA expression of inflammatory cytokines in placenta and preschoolers' cognitive performance.

Methods

Study subjects were obtained from the Ma'anshan birth cohort (MABC). Placental samples were collected after delivery, and real-time quantitative polymerase chain reaction (RT-qPCR) was utilized to measure the mRNA expression levels of IL-8, IL-1β, IL-6, TNF-α, CRP, IFN-γ, IL-10, and IL-4. Children's intellectual d

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10658981 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature