Identifying individualized prognostic signature and unraveling the molecular mechanism of recurrence in early-onset colorectal cancer.

ABSTRACT:

Background

The incidence and mortality of early-onset colorectal cancer (EOCRC; < 50 years old) is increasing worldwide, with a high recurrence rate. The inherent heterogeneity of EOCRC makes its treatment challenging. Hence, to further understand the biology and reveal the molecular mechanisms of EOCRC, a recurrence risk signature is needed to guide clinical management.

Methods

Based on the relative expression orderings (REOs) of genes in each sample, a prognostic signature was developed and validated utilizing multiple independent datasets. The underlying molecular mechanisms between distinct prognostic groups were explored via integrative analysis of multi-omics data.

Results

The prognostic signature consisting of 6 gene pairs (6-GPS) could predict the recurrence r

SUBMITTER: Yang J 

PROVIDER: S-EPMC10658991 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature