Transcrocetin meglumine salt inhibits spinal glial cell-mediated proinflammatory cytokines and attenuates complete Freund's adjuvant-induced inflammatory pain.

ABSTRACT:

Introduction

Inflammatory pain is a significant global clinical challenge that involves both unpleasant sensory and emotional experiences. The treatment of pain is imminent, and we are committed to seeking new analgesics for pain relief. Transcrocetin meglumine salt (TCMS), a saffron metabolite derived from the crocin apocarotenoids, has exhibited the ability to cross the blood-brain barrier and exert neuroprotective effects. In this study, we aimed to investigate whether TCMS could ameliorate complete Freund's adjuvant (CFA)-induced inflammatory pain in mice and elucidate its underlying mechanisms.

Methods

Here, we established an inflammatory pain model in mice by injecting CFA into the left hind paw. Three days later, we administered intraperitoneal injections of TCMS (10m

SUBMITTER: Qiao Q 

PROVIDER: S-EPMC10659006 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature