Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants.

ABSTRACT:

Background and objective

Knowledge about exposure to cannabidiol (CBD) in breastfed infants can provide an improved understanding of potential risk. The aim was to predict CBD exposure in breastfed infants from mothers taking CBD and CBD-containing products.

Methods

Cannabidiol concentrations in milk previously attained from data collected through an existing human milk research biorepository were used to simulate infant doses and identify subgroups. A developed pediatric physiologically based pharmacokinetic model produced virtual breastfed infants administered the simulated CBD doses. Predicted breastfed infant exposures and upper area under the curve ratios were compared to the lowest therapeutic dose for approved indications in children.

Results

The existing human

SUBMITTER: Yeung CHT 

PROVIDER: S-EPMC10659070 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature