Oral follicle-stimulating hormone receptor agonist affects granulosa cells differently than recombinant human FSH.

ABSTRACT:

Objective

To determine whether TOP5300, a novel oral follicle-stimulating hormone (FSH) receptor (FSHR) allosteric agonist, elicits a different cellular response than recombinant human FSH (rh-FSH) in human granulosa cells from patients undergoing in vitro fertilization.

Design

Basic science research with a preclinical allosteric FSHR agonist.

Setting

University hospital.

Patient(s)

Patients with infertility at a single academic fertility clinic were recruited under an Institutional Review Board-approved protocol. Primary granulosa cell cultures were established for 41 patients, of whom 8 had normal ovarian reserve (NOR), 17 were of advanced reproductive age (ARA), 12 had a diagnosis of polycystic ovary syndrome (PCOS), and 4 had a combination of diagnoses, suc

SUBMITTER: Guner JZ 

PROVIDER: S-EPMC10659100 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature