Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner.

ABSTRACT: Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking Fndc5 (KO), with and without calcium deficiency. Despite their bone being indistinguishable from WT females, KO female mice were partially protected from osteocytic osteolysis and osteoclastic bone resorption when allowed to lactate or when placed on a low-calcium diet. Male KO mice have more but weaker bone compared to WT males, and when challenged with a low-calcium diet lost more bone than WT males. To begin to understand responsible molecular mechanisms, osteocyte transcriptomics was performed. Osteocytes from WT females had greater expr

SUBMITTER: Shimonty A 

PROVIDER: S-EPMC10659274 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature