Are <i>Escherichia coli</i> causing recurrent cystitis just ordinary Uropathogenic <i>E. coli</i> (UPEC) strains?

ABSTRACT: Specific determinants associated with Uropathogenic Escherichia coli (UPEC) causing recurrent cystitis are still poorly characterized. The aims of this study were (i) to describe genomic and phenotypic traits associated with recurrence using a large collection of recurrent and paired sporadic UPEC isolates, and (ii) to explore within-host genomic adaptation associated with recurrence using series of 2 to 5 sequential UPEC isolates. Whole genome comparative analyses between 24 recurrent cystitis isolates (RCIs) and 24 phylogenetically paired sporadic cystitis isolates (SCIs) suggested a lower prevalence of putative mobile genetic elements (MGE) in RCIs, such as plasmids and prophages. The intra-patient evolution of the 24 RCI series over time was characterized by SNP occurrence in ge

SUBMITTER: Vautrin N 

PROVIDER: S-EPMC10659292 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature