Dual effects of the small-conductance Ca²⁺-activated K⁺ current on human atrial electrophysiology and Ca²⁺-driven arrhythmogenesis: an in silico study.

ABSTRACT: By sensing changes in intracellular Ca²⁺, small-conductance Ca²⁺-activated K⁺ (SK) channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to-beat basis. Given their predominance in atria versus ventricles, SK channels are considered a promising atrial-selective pharmacological target against atrial fibrillation (AF), the most common cardiac arrhythmia. However, the precise contribution of SK current (I_SK) to atrial arrhythmogenesis is poorly understood, and may potentially involve different mechanisms that depend on species, heart rates, and degree of AF-induced atrial remodeling. Both reduced and enhanced I_SK have been linked to AF. Similarly, both SK channel up- and downregulation have

SUBMITTER: Herrera NT 

PROVIDER: S-EPMC10659325 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature