A vasopressin circuit that modulates sex-specific social interest and anxiety-like behavior in mice.

ABSTRACT: One of the largest sex differences in brain neurochemistry is the male-biased expression of the neuropeptide arginine vasopressin (AVP) within the vertebrate social brain. Despite the long-standing implication of AVP in social and anxiety-like behavior, the precise circuitry and anatomical substrate underlying its control are still poorly understood. By employing optogenetic manipulation of AVP cells within the bed nucleus of the stria terminalis (BNST), we have unveiled a central role for these cells in promoting social investigation, with a more pronounced role in males relative to females. These cells facilitate male social investigation and anxiety-like behavior through their projections to the lateral septum (LS), an area with the highest density of sexually-dimorphic AVP fibers. Bloc

SUBMITTER: Rigney N 

PROVIDER: S-EPMC10659331 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature