Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila.

ABSTRACT: Actin cortex patterning and dynamics are critical for cell shape changes. These dynamics undergo transitions during development, often accompanying changes in collective cell behavior. While mechanisms have been established for individual cells' dynamic behaviors, mechanisms and specific molecules that result in developmental transitions in vivo are still poorly understood. Here, we took advantage of two developmental systems in Drosophila melanogaster to identify conditions that altered cortical patterning and dynamics. We identified a RhoGEF and RhoGAP pair whose relocalization from nucleus to cortex results in actomyosin waves in egg chambers. Furthermore, we found that overexpression of a different RhoGEF and RhoGAP pair resulted in actomyosin waves in the early embryo, during w

SUBMITTER: Jackson JA 

PROVIDER: S-EPMC10659369 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature