Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics.

ABSTRACT: Juvenile Dermatomyositis (JDM) is one of several childhood-onset autoimmune disorders characterized by a type I interferon response and autoantibodies. Treatment options are limited due to incomplete understanding of how the disease emerges from dysregulated cell states across the immune system. We therefore investigated the blood of JDM patients at different stages of disease activity using single-cell transcriptomics paired with surface protein expression. By immunophenotyping peripheral blood mononuclear cells, we observed skewing of the B cell compartment towards an immature naive state as a hallmark of JDM. Furthermore, we find that these changes in B cells are paralleled by signatures of Th2-mediated inflammation. Additionally, our work identified SIGLEC-1 expression in monocytes as

SUBMITTER: Rabadam G 

PROVIDER: S-EPMC10659396 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature