MCU-enriched dendritic mitochondria regulate plasticity in distinct hippocampal circuits.

ABSTRACT: Mitochondria are dynamic organelles that are morphologically and functionally diverse across cell types and subcellular compartments in order to meet unique energy demands. Mitochondrial dysfunction has been implicated in a wide variety of neurological disorders, including psychiatric disorders like schizophrenia and bipolar disorder. Despite it being well known that mitochondria are essential for synaptic transmission and synaptic plasticity, the mechanisms regulating mitochondria in support of normal synapse function are incompletely understood. The mitochondrial calcium uniporter (MCU) regulates calcium entry into the mitochondria, which in turn regulates the bioenergetics and distribution of mitochondria to active synapses. Evidence suggests that calcium influx via MCU couples neuronal

SUBMITTER: Pannoni KE 

PROVIDER: S-EPMC10659405 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature