Tissue-resident alveolar macrophages reduce O₃-induced inflammation via MerTK mediated efferocytosis.

ABSTRACT: Lung inflammation, caused by acute exposure to ozone (O₃) - one of the six criteria air pollutants - is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung and their number increases following O₃ exposure. However, the role of AMØs in promoting or limiting O₃-induced lung inflammation has not been clearly defined. Here, we used a mouse model of acute O₃ exposure, lineage tracing, genetic knockouts, and data from O₃-exposed human volunteers to define the role and ontogeny of AMØs during acute O₃ exposure. Lineage tracing experiments showed that 12, 24, and 72 h after exposure to O₃ (2 ppm) for 3h all AMØs were tissue-residen

SUBMITTER: Guttenberg MA 

PROVIDER: S-EPMC10659406 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature