Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study.

ABSTRACT:

Background

People with HIV (PWH) have lower exercise capacity compared to HIV-uninfected peers, which may be explained by chronotropic incompetence (CI), the inability to increase heart rate during exercise.

Methods

The Exercise for Healthy Aging Study included adults ages 50-75 with and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization to moderate or high intensity for 12 additional weeks. We compared adjusted heart rate reserve (AHRR; CI <80%) on cardiopulmonary exercise testing by HIV serostatus, and change from baseline to 12 and 24 weeks using mixed effects models.

Results

Among 32 PWH and 37 controls (median age 56, 7% female, mean BMI 28 kg/m²), 28% of PWH compared to 11% of controls had CI at baseline

SUBMITTER: Durstenfeld MS 

PROVIDER: S-EPMC10659453 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature