Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations.

ABSTRACT:

Background

Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular diseases (CVD), the leading cause of mortality and morbidity worldwide. In response to microenvironment alterations, SMCs dedifferentiate from a "contractile" to a "synthetic" phenotype characterized by an increased proliferation, migration, production of extracellular matrix (ECM) components, and decreased expression of SMC-specific contractile markers. These phenotypic changes result in vascular remodeling and contribute to the pathogenesis of CVD, including coronary artery disease (CAD), stroke, hypertension, and aortic aneurysms. Here, we aim to identify the genetic variants that regulate ECM secretion in SMCs and predict the causal proteins associate

SUBMITTER: Aherrahrou R 

PROVIDER: S-EPMC10659471 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature