Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease.

ABSTRACT: The current demand for early intervention, prevention, and treatment of late onset Alzheimer's disease (LOAD) warrants deeper understanding of the underlying molecular processes which could contribute to biomarker and drug target discovery. Utilizing high-throughput proteomic measurements in serum from a prospective population-based cohort of older adults (n=5,294), we identified 303 unique proteins associated with incident LOAD (median follow-up 12.8 years). Over 40% of these proteins were associated with LOAD independently of APOE-ε4 carrier status. These proteins were implicated in neuronal processes and overlapped with protein signatures of LOAD in brain and cerebrospinal fluid. We found 17 proteins which LOAD-association was strongly dependent on APOE

SUBMITTER: Frick EA 

PROVIDER: S-EPMC10659486 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature