HDL Particle Concentration and Size Predict Incident Coronary Artery Disease Events in People with Type 1 Diabetes.

ABSTRACT:

Background

Cholesterol efflux capacity (CEC) negatively correlates with cardiovascular disease risk. Small HDL particles account almost quantitively for CEC, perhaps mediated through efflux of outer leaflet plasma membrane phospholipids by ABCA1. People with type 1 diabetes (T1D) are at increased risk of coronary artery disease (CAD) despite normal levels of HDL-cholesterol (HDL-C). We therefore tested the hypotheses that small HDL particles (HDL-P)-rather than HDL-C levels-predict incident CAD in T1D.

Methods

Incident CAD (CAD death, myocardial infarction, and/or coronary revascularization) was determined in a cohort of 550 participants with childhood-onset T1D. HDL-P was quantified by calibrated ion mobility analysis. CEC and phospholipid efflux were quantified with valida

SUBMITTER: Costacou T 

PROVIDER: S-EPMC10659494 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature