Dataset Information

Associations between D₃Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

ABSTRACT:

Background

Different measures to assess muscle size - magnetic resonance (MR) derived thigh muscle volume and d3-creatine dilution derived muscle mass (D₃Cr muscle mass) - may have similar associations with strength, power, physical performance, fitness, and functional limitations in older adults.

Methods

Men (N=345) and women (N=482) aged ≥70 years from the Study of Muscle, Mobility and Aging completed exams including leg extension strength (1-repetition max) and cardiopulmonary exercise testing to assess fitness (VO₂peak). Correlations and adjusted regression models stratified by sex were used to assess the association between muscle size measures and study outcomes; we tested for sex interactions.

Results

D₃Cr muscle mass and MR thigh muscle volume were correlated (men: r=0.62, women: r=0.51, p<.001). Lower D₃Cr muscle mass and lower MR thigh muscle volume were associated with lower strength and lower VO₂peak in both men and women; D₃Cr muscle mass was more strongly associated with strength in men than in women (p-int<0.05). There were correlations, though less consistent, between muscle size or mass with physical performance and function. Associations between the muscle size measures and the study outcomes occasionally varied by sex, and associations of MR thigh muscle volume were, at times, slightly more strongly associated with the study outcomes than was D₃Cr muscle mass.

Conclusions

Less muscle -measured by either D₃Cr muscle mass or MR thigh muscle volume - was associated with lower strength and worse performance. Varied associations by sex and assessment method suggest consideration be given to which measurement to use in future studies.

SUBMITTER: Cawthon PM

PROVIDER: S-EPMC10659521 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Associations between D<sub>3</sub>Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

Cawthon Peggy M PM Blackwell Terri L TL Kritchevsky Stephen B SB Newman Anne B AB Hepple Russell T RT Coen Paul M PM Goodpaster Bret H BH Duchowny Kate K Hetherington-Rauth Megan M Mau Theresa T Shankaran Mahalakshmi M Hellerstein Marc M Evans William J WJ Cummings Steven R SR

medRxiv : the preprint server for health sciences 20231110

<h4>Background</h4>Different measures to assess muscle size - magnetic resonance (MR) derived thigh muscle volume and d3-creatine dilution derived muscle mass (D<sub>3</sub>Cr muscle mass) - may have similar associations with strength, power, physical performance, fitness, and functional limitations in older adults.<h4>Methods</h4>Men (N=345) and women (N=482) aged ≥70 years from the Study of Muscle, Mobility and Aging completed exams including leg extension strength (1-repetition max) and cardi ...[more]

PMID: 37986809

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Project description:Muscle mass and strength are crucial for physiological function and performance in athletes, playing a significant role in maintaining health and optimal athletic performance. Skeletal muscle, which constitutes the majority of lean soft tissue (LST) and appendicular lean soft tissue (ALST) when measured by dual-energy X-ray absorptiometry (DXA), represents a commonly used surrogate for strength. Research has investigated alternative measures of body composition, such as the assessment of ALST through bioelectrical impedance analysis (BIA) and the determination of whole-body muscle mass from creatine pool size using the deuterated creatine (D3Cr) dilution method, for their associations to strength. While the relationship between body composition measures and strength has been studied in older adults, this relationship remains unexplored in athletic populations. This study examined muscle body composition measures using DXA, D3Cr, and BIA and their association with strength in a sample of collegiate athletes. The study enrolled 80 collegiate athletes (40 females) of differing sports disciplines who consumed a 60 mg dose of D3Cr and completed DXA and BIA measures in addition to trunk and leg strength tests. Analysis was sex-stratified using Pearson's correlations, linear regression, and quartile p trend significance. With an average participant age of 21.8 years, whole-body DXA correlations to muscle strength surpassed height- or mass-normalized values. This trend was especially pronounced in trunk strength's relationship with body composition over leg strength, across measurement methods. While DXA LST values were higher than BIA and D3Cr in predicting strength, the values did not differ significantly. Adjustments for age, BMI, and BIA variables didn't enhance this association. A significant trend between DXA LST and all strength measures underscored the equal relevance of DXA and D3Cr muscle mass to strength, favoring whole-body over regional assessments. This calls for future research on muscle mass's effects on LST and functional outcomes in broader groups, highlighting the importance of comprehensive body composition analysis in athletic performance studies.

Project description:BackgroundMuscle fat infiltration (MFI) is increasingly recognized as a critical factor influencing muscle function and metabolic health. Accurate quantification of MFI is essential for diagnosing and monitoring various muscular and metabolic disorders. Quantitative Dixon (Q-Dixon) magnetic resonance imaging (MRI) and high-speed T2-corrected multi-echo (HISTO) magnetic resonance spectroscopy (MRS) are both advanced imaging techniques that offer potential for detailed assessment of MFI. However, the validity and reliability of these methods in measuring volumetric changes in muscle composition, particularly in both thigh and paravertebral muscles, have not been thoroughly compared. This study aims to validate volumetric measurements using Q-Dixon MRI against HISTO MRS in thigh and paravertebral muscles, taking into account the heterogeneity of MFI.MethodsA retrospective study was conducted with 54 subjects [mean age, 60 years; 38 male (M)/16 female (F)] for thigh muscle and 56 subjects (mean age, 50 years; 22 M/34 F) for paravertebral muscle assessment using a 3-Tesla MRI. The proton density fat fraction (PDFF) was measured with Q-Dixon MRI and HISTO MRS within the upper-middle part of quadriceps femoris and paravertebral muscles at L4/5 level in volumes-of-interest (VOIs). The corresponding volumetric Q-Dixon freehand VOI PDFF was measured. Scatterplots, Bland-Altman plots, Spearman correlation coefficients, and Wilcoxon signed rank test with Bonferroni correction were employed. The Kruskal-Wallis H tests followed by Bonferroni-corrected post hoc tests were analyzed to compare parameter differences with visual MFI grades.ResultsQ-Dixon cubic VOI PDFF correlated positively with HISTO MRS PDFF in thigh (r=0.96, P<0.001) and paravertebral groups (r=0.98, P<0.001), with insignificant differences (P=0.29, 0.82, respectively). Both PDFF values from cubic VOIs in Q-Dixon and HISTO MRS differed from the freehand Q-Dixon PDFF (all P<0.001). Only for <5% HISTO MRS PDFF, there was a difference between HISTO MRS PDFF and Q-Dixon cubic VOI PDFF (P=0.002).ConclusionsVolumetric Q-Dixon cubic VOI PDFF exhibited good correlation and consistency with HISTO MRS PDFF for quantitative fat assessment in thigh and paravertebral muscles except for muscles with fat fraction <5%, and the Q-Dixon freehand VOI PDFF offers a more comprehensive assessment of the actual MFI compared to cubic VOI.

Dataset Information

Associations between D₃Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

Background

Methods

Results

Conclusions

Publications

Associations between D<sub>3</sub>Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

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OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Associations between D3Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

Background

Methods

Results

Conclusions

Publications

Associations between D&lt;sub&gt;3&lt;/sub&gt;Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Associations between D₃Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.

Associations between D<sub>3</sub>Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study.