Resolvin D1 promotes the resolution of inflammation in the ACLF rat model by increasing the proportion of Treg cells.

ABSTRACT:

Objective

Acute-on-chronic liver failure (ACLF) causes organ system failures in patients and increases the risk of mortality. One of the main predictors of ACLF development in patients is the severity of systemic inflammation. The purpose of this study was to explore the effects of resolvin D1 (RvD1) on the rat model of ACLF.

Methods

The ACLF rats were induced by first intraperitoneally (ip) injecting CCl₄ and porcine serum for 6 weeks to establish the chronic liver injury, followed by once administration (ip) of lipopolysaccharide and d-galactose d-GalN to cause acute liver injury (ALI). An hour before the ALI-induced treatment, rats were administrated (ip) with 0.9% saline or different doses of RvD1 (0.3 or 1 µg/kg). Afterward, the control and treated rats were

SUBMITTER: Chen L 

PROVIDER: S-EPMC10659757 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature