Infertility and Risk of Autism Spectrum Disorder in Children.

ABSTRACT:

Importance

Previous studies on the risk of childhood autism spectrum disorder (ASD) following fertility treatment did not account for the infertility itself or the mediating effect of obstetrical and neonatal factors.

Objective

To assess the association between infertility and its treatments on the risk of ASD and the mediating effect of selected adverse pregnancy outcomes on that association.

Design, setting, and participants

This was a population-based cohort study in Ontario, Canada. Participants were all singleton and multifetal live births at 24 or more weeks' gestation from 2006 to 2018. Data were analyzed from October 2022 to October 2023.

Exposures

The exposure was mode of conception, namely, (1) unassisted conception, (2) infertility without fertility

SUBMITTER: Velez MP 

PROVIDER: S-EPMC10660172 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature