Deficit Accumulation Index and Biological Markers of Aging in Survivors of Childhood Cancer.

ABSTRACT:

Importance

Survivors of childhood cancer experience premature aging compared with community controls. The deficit accumulation index (DAI) uses readily available clinical data to measure physiological age in survivors; however, little data exist on how well deficit accumulation represents underlying biological aging among survivors of cancer.

Objective

To examine the associations between the DAI and epigenetic age acceleration (EAA) and mean leukocyte telomere length (LTL).

Design, setting, and participants

This cross-sectional study analyzed data from the St Jude Lifetime Cohort, an assessment of survivors of childhood cancer who were treated at St Jude Children's Research Hospital in Memphis, Tennessee. Data were collected between 2007 and 2016, assayed between 2014

SUBMITTER: Williams AM 

PROVIDER: S-EPMC10660189 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature