Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia.

ABSTRACT: UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co-mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF-TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF-TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.

SUBMITTER: Harrop S 

PROVIDER: S-EPMC10660390 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature