Pan-cancer analyses of senescence-related genes in extracellular matrix characterization in cancer.

ABSTRACT:

Purpose

The aged microenvironment plays a crucial role in tumor onset and progression. However, it remains unclear whether and how the aging of the extracellular matrix (ECM) influences cancer onset and progression. Furthermore, the mechanisms and implications of extracellular matrix senescence-related genes (ECM-SRGs) in pan-cancer have not been investigated.

Methods

We collected profiling data from over 10,000 individuals, covering 33 cancer types, 750 small molecule drugs, and 24 immune cell types, for a thorough and systematic analysis of ECM-SRGs in cancer.

Results

We observed a significant correlation between immune cell infiltrates and Gene Set Variation Analysis enrichment scores of ECM-SRGs in 33 cancer types. Moreover, our results revealed significant differ

SUBMITTER: Yan B 

PROVIDER: S-EPMC10660488 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature