Comprehensive Analysis of Titanium Oxide Nanoparticle Size and Surface Properties on Neuronal PC-12 Cells: Unraveling Cytotoxicity, Dopaminergic Gene Expression, and Acetylcholinesterase Inhibition.

ABSTRACT: Titanium oxide nanoparticles can penetrate the blood-brain barrier, infiltrate the central nervous system, and induce neurotoxicity. One of the most often utilized nanoparticles has been investigated for their neurotoxicity in many studies. Nonetheless, there remains an unexplored aspect regarding the comparative analysis of particles varying in size and nanoparticles of identical dimensions, both with and devoid of surface coating. In the current study, we synthesized two differently sized nanoparticles, TiO₂-10 (10 nm) and TiO₂-22 (22 nm), and nanoparticles of the same size but with a polyvinylpyrrolidone surface coating (TiO₂-PVP, 22 nm) and studied their toxic effects on neural PC-12 cells. The results highlighted significant dose- and time-dependent cy

SUBMITTER: Suthar JK 

PROVIDER: S-EPMC10660528 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature