A Pediatric Upper Airway Library to Evaluate Interpatient Variability of In Silico Aerosol Deposition.

ABSTRACT: The airway of pediatric patients' changes through development, presenting a challenge in developing pediatric-specific aerosol therapeutics. Our work aims to quantify geometric variations and aerosol deposition patterns during upper airway development in subjects between 3.5 months-6.9 years old using a library of 24 pediatric models and 4 adult models. Computational fluid-particle dynamics was performed with varying particle size (0.1-10 μm) and flow rate (10-120 Lpm), which was rigorously analyzed to compare anatomical metrics (epiglottis angle (θ_E), glottis to cricoid ring ratio (GC-ratio), and pediatric to adult trachea ratio (H-ratio)), inhaler metrics (particle diameter, [Formula: see text], and flow rate, Q), and clinical metrics (age, sex, height, and weight) against aer

SUBMITTER: Kolewe EL 

PROVIDER: S-EPMC10660588 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature