Protocol for SNOTOB study: radical prostatectomy without prostate biopsy following ¹⁸F-PSMA-1007 PET/CT based on a diagnostic model: a single-centre, single-arm, open-label study.

ABSTRACT:

Introduction

Nowadays, invasive prostate biopsy is the standard diagnostic test for patients with suspected prostate cancer (PCa). However, it has some shortcomings such as perioperative complications, economic and psychological burden on patients, and some patients may undergo repeated prostate biopsy. In this study protocol, our aim is to provide a non-invasive diagnostic strategy we call the 'prostate-specific membrane antigen (PSMA) combined model' for the diagnosis of PCa. If patients are diagnosed with PCa using PSMA combined model, we want to prove these patients can receive radical prostatectomy directly without prior prostate biopsies.

Methods

The SNOTOB trial adopts a prospective, single-centre, single-arm, open-label study design. The PSMA combined model consists

SUBMITTER: Wang C 

PROVIDER: S-EPMC10660686 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature