REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol.

ABSTRACT:

Introduction

The Re-Evaluating the Inhibition of Stress Erosions (REVISE) Trial aims to determine the impact of the proton pump inhibitor pantoprazole compared with placebo on clinically important upper gastrointestinal (GI) bleeding in the intensive care unit (ICU), 90-day mortality and other endpoints in critically ill adults. The objective of this report is to describe the rationale, methodology, ethics and management of REVISE.

Methods and analysis

REVISE is an international, randomised, concealed, stratified, blinded parallel-group individual patient trial being conducted in ICUs in Canada, Australia, Saudi Arabia, UK, US, Kuwait, Pakistan and Brazil. Patients≥18 years old expected to remain invasively mechanically ventilated beyond th

SUBMITTER: Deane AM 

PROVIDER: S-EPMC10660838 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature