Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care.

ABSTRACT:

Purpose

The diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs. Therefore, a screening algorithm was previously developed for the early detection of patients at risk of PAD in primary care. We aimed to clinically validate and optimize the PAD screening algorithm by applying it to a primary care database in the Netherlands.

Methods

The algorithm was applied to a data set of 61,172 electronic health records (EHRs). Four hundred high-scoring EHRs were screened for exclusion criteria, and remaining patients were invited for serum immunoglobulin analysis and referred if clinically necessary.

Results

Of the 104 patients eligible for inclusion, 16 were referred by their general practitioner for sus

SUBMITTER: Messelink MA 

PROVIDER: S-EPMC10660978 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature