Negative emotion reduces the discriminability of reward outcomes in the ventromedial prefrontal cortex.

ABSTRACT: Reward and emotion are tightly intertwined, so there is a growing interest in mapping their interactions. However, our knowledge of these interactions in the human brain, especially during the consummatory phase of reward is limited. To address this critical gap, we conducted a functional magnetic resonance imaging study to investigate the effects of negative emotion on reward outcome processing. We employed a novel design where emotional valence (negative or neutral) indicated the type of outcome (reward or no-reward) in a choice task. We focused our functional magnetic resonance imaging analysis on the ventro-medial prefrontal cortex (vmPFC), ventral striatum and amygdala, which were frequently implicated in reward outcome processing. In these regions of interest, we performed multi-voxe

SUBMITTER: Chakravarthula LNC 

PROVIDER: S-EPMC10661064 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature