Characteristics and metabolic potential of biliary microbiota in patients with giant common bile duct stones.

ABSTRACT:

Background

Endoscopic retrograde cholangiopancreatography (ERCP) is an effective minimally invasive operation for the management of choledocholithiasis, while successful extraction is hampered by large diameter of stones. Emerging studies have revealed the close correlation between biliary microbiota and common bile duct stones (CBDS). In this study, we aimed to investigate the community characteristics and metabolic functions of biliary microbiota in patients with giant CBDS.

Methods

Eligible patients were prospectively enrolled in this study in First Affiliated Hospital of Soochow University from February 2022 to October 2022. Bile samples were collected through ERCP. The microbiota was analyzed using 16S rRNA sequencing. Metabolic functions were predicted by PICRUSTs 2.0

SUBMITTER: Dai C 

PROVIDER: S-EPMC10661410 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature