Propofol EC₅₀ for inducing loss of consciousness in patients under combined epidural-general anesthesia or general anesthesia alone: a randomized double-blind study.

ABSTRACT:

Background

Combined epidural-general anesthesia (GA + EA) has been recommended as a preferred technique for both thoracic and abdominal surgery. The epidural anesthesia on the general anesthetic (GA) requirements has not been well investigated. Therefore, we conducted the present study to explore the predicted effect-site concentration of propofol (Ce_prop) required for achieving the loss of consciousness (LOC) in 50% of patients (EC₅₀) with or without epidural anesthesia.

Methods

Sixty patients scheduled for gastrectomy were randomized into the GA + EA group or GA alone group to receive general anesthesia alone. Ropivacaine 0.375% was used for epidural anesthesia to achieve a sensory level of T4 or above prior to the induction of general anesthesia. The

SUBMITTER: Wang J 

PROVIDER: S-EPMC10661411 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature