Disease activity in primary progressive multiple sclerosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Disease activity in multiple sclerosis (MS) is defined as presence of relapses, gadolinium enhancing lesions and/or new or enlarging lesions on MRI. It is associated with efficacy of immunomodulating therapies (IMTs) in primary progressive MS (PPMS). However, a thorough review on disease activity in PPMS is lacking. In relapsing remitting MS, the prevalence of activity decreases in more contemporary cohorts. For PPMS, this is unknown.

Aim

To review disease activity in PPMS cohorts and identify its predictors.

Methods

A systematic search in EMBASE, MEDLINE, Web of science Core Collection, COCHRANE CENTRAL register of trials, and GOOGLE SCHOLAR was performed. Keywords included PPMS, inflammation, and synonyms. We included original studies with predefined avai

SUBMITTER: Blok KM 

PROVIDER: S-EPMC10661414 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature