Poly(ADP-ribosyl)ating enzymes coordinate changes in the expression of metabolic genes with developmental progression.

ABSTRACT: Metabolism, known to be temporally regulated to meet evolving energy demands, plays a crucial role in shaping developmental pace. Recent studies have demonstrated that two key proteins PARP1 and PARG play a regulatory role in the transcription of both morphogenic and metabolic genes. Intriguingly, in Drosophila, the depletion of PARP1 or PARG proteins causes a developmental arrest before pupation, resulting in individuals unable to complete their development. This phenotype highlights the critical involvement of poly(ADP-ribosyl)ating enzymes in regulating the metamorphic process. In this study, we provide compelling evidence that these enzymes intricately coordinate transcriptional changes in both developmental and metabolic pathways during metamorphosis. Specifically, they promote the ex

SUBMITTER: Bordet G 

PROVIDER: S-EPMC10661653 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature