Parallel detection of chemical reactions in a microfluidic platform using hyperpolarized nuclear magnetic resonance.

ABSTRACT: The sensitivity of NMR may be enhanced by more than four orders of magnitude via dissolution dynamic nuclear polarization (dDNP), potentially allowing real-time, in situ analysis of chemical reactions. However, there has been no widespread use of the technique for this application and the major limitation has been the low experimental throughput caused by the time-consuming polarization build-up process at cryogenic temperatures and fast decay of the hyper-intense signal post dissolution. To overcome this limitation, we have developed a microfluidic device compatible with dDNP-MR spectroscopic imaging methods for detection of reactants and products in chemical reactions in which up to 8 reactions can be measured simultaneously using a single dDNP sample. Multiple MR spectrosc

SUBMITTER: Yeste J 

PROVIDER: S-EPMC10661666 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature