Risk Stratification Model for Hepatocellular Cancer in Patients With Cirrhosis.

ABSTRACT:

Background & aims

The available risk stratification indices for hepatocellular cancer (HCC) have limited applicability. We developed and externally validated an HCC risk stratification index in U.S. cohorts of patients with cirrhosis.

Methods

We used data from 2 prospective U.S. cohorts to develop the risk index. Patients with cirrhosis were enrolled from 8 centers and followed until development of HCC, death, or December 31, 2021. We identified an optimal set of predictors with the highest discriminatory ability (C-index) for HCC. The predictors were refit using competing risk regression and its predictive performance was evaluated using the area under the receiver-operating characteristic curve (AUROC). External validation was performed in a cohort of 21,550 patients with

SUBMITTER: Kanwal F 

PROVIDER: S-EPMC10661677 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature