Chronic Granulomatous Disease: a Cohort of 173 Patients-10-Years Single Center Experience from Egypt.

ABSTRACT:

Purpose

Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder of phagocytes, characterized by recurrent fungal and bacterial infections. Our aim is to describe the different clinical presentations, non-infectious auto-inflammatory features, types and sites of infections, and to estimate the mortality among our large cohort.

Methods

This is a retrospective study conducted at the Pediatric Department of Cairo University Children's Hospital in Egypt, including cases with a confirmed CGD diagnosis.

Results

One hundred seventy-three confirmed CGD patients were included. AR-CGD was diagnosed in 132 patients (76.3%) including 83 patients (48%) with p47^phox defect, 44 patients (25.4%) with p22^phox defect, and 5 patients (2

SUBMITTER: Abd Elaziz D 

PROVIDER: S-EPMC10661789 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature