Psychedelics action and schizophrenia.

ABSTRACT: Psychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT)_2A receptor activation and induce several behavioral responses. They are of special interest because of their positive effects on neuropsychiatric disorders (depression and posttraumatic stress disorder). However, several findings revealed that some psychedelic actions are similar to symptoms observed in schizophrenia (psychosis, sensorimotor gating impairments, attention, and working memory deficits) which might limit their clinical applications. Psychedelics activate some neurotransmitters, i.e., serotonergic, and glutamatergic, that are also impaired in schizophrenia. Therefore, the neurobiological background of psychedelics and schizophrenia is partially similar. Another important aspect to discuss is t

SUBMITTER: Mackowiak M 

PROVIDER: S-EPMC10661800 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature