Dataset Information

Seasonal and inter-seasonal RSV activity in the European Region during the COVID-19 pandemic from autumn 2020 to summer 2022.

ABSTRACT:

Background

The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in early 2020 and subsequent implementation of public health and social measures (PHSM) disrupted the epidemiology of respiratory viruses. This work describes the epidemiology of respiratory syncytial virus (RSV) observed during two winter seasons (weeks 40-20) and inter-seasonal periods (weeks 21-39) during the pandemic between October 2020 and September 2022.

Methods

Using data submitted to The European Surveillance System (TESSy) by countries or territories in the World Health Organization (WHO) European Region between weeks 40/2020 and 39/2022, we aggregated country-specific weekly RSV counts of sentinel, non-sentinel and Severe Acute Respiratory Infection (SARI) surveillance specimens and calculated percentage positivity. Results for both 2020/21 and 2021/22 seasons and inter-seasons were compared with pre-pandemic 2016/17 to 2019/20 seasons and inter-seasons.

Results

Although more specimens were tested than in pre-COVID-19 pandemic seasons, very few RSV detections were reported during the 2020/21 season in all surveillance systems. During the 2021 inter-season, a gradual increase in detections was observed in all systems. In 2021/22, all systems saw early peaks of RSV infection, and during the 2022 inter-seasonal period, patterns of detections were closer to those seen before the COVID-19 pandemic.

Conclusion

RSV surveillance continued throughout the COVID-19 pandemic, with an initial reduction in transmission, followed by very high and out-of-season RSV circulation (summer 2021) and then an early start of the 2021/22 season. As of the 2022/23 season, RSV circulation had not yet normalised.

SUBMITTER: Mesle MMI

PROVIDER: S-EPMC10661829 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Seasonal and inter-seasonal RSV activity in the European Region during the COVID-19 pandemic from autumn 2020 to summer 2022.

Meslé Margaux M I MMI Sinnathamby Mary M Mook Piers P Pebody Richard R Lakhani Anissa A Zambon Maria M Popovici Odette O Lazăr Mihaela M Ljubović Amela Dedeić AD Vukmir Nina Rodić NR Altaş Ayşe Başak AB Avci Emine E Łuniewska Katarzyna K Szymański Karol K Gargasiene Greta G Muralyte Svajune S Dziugyte Ausra A Zahra Graziella G Gonçalves Ana Rita AR Spedaliero Tania T Fournier Guillaume G Alvarez-Vaca Daniel D Petrović Goranka G Tabain Irena I Prosenc Katarina K Socan Maja M Protic Jelena J Dimitrijevic Dragana D Druc Alina A Apostol Mariana M Kalasnikova Kate Karolina KK Nikisins Sergejs S Reiche Janine J Cai Wei W Meijer Adam A Teirlinck Anne A Larrauri Amparo A Casas Inmaculada I Enouf Vincent V Vaux Sophie S Lomholt Frederikke Kristensen FK Trebbien Ramona R Jirincova Helena H Sebestova Helena H Rózsa Mónika M Molnár Zsuzsanna Z Aspelund Gudrun G Baldvinsdottir Gudrun Erna GE Cottrell Simon S Moore Catherine C Kossyvakis Athanasios A Mellou Kassiani K Sadikova Olga O Tamm Johanna Kristina JK Bossuyt Nathalie N Thomas Isabelle I Staroňová Edita E Kudasheva Lyudmila L Pleshkov Boris B Ikonen Niina N Helve Otto O Dickson Emma E Curran Tanya T Komissarova Kseniya K Stolyarov Kirill K Vysotskaya Veronika V Shmialiova Natallia N Rakočević Božidarka B Vujošević Danijela D Abovyan Romella R Sargsyan Shushan S Zakhashvili Khatuna K Machablishvili Ann A Koshalko Oksana O Demchyshyna Iryna I Mandelboim Michal M Glatman-Freedman Aharona A Gunson Rory R Karanwal Shivani S Guiomar Raquel R Rodrigues Ana Paula AP Bennett Charlene C Domegan Lisa L Kalaveshi Arijana A Jakupi Xhevat X Ovliyakulova Gurbangul G Korsun Neli N Vladimirova Nadezhda N

Influenza and other respiratory viruses 20231120 11

<h4>Background</h4>The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in early 2020 and subsequent implementation of public health and social measures (PHSM) disrupted the epidemiology of respiratory viruses. This work describes the epidemiology of respiratory syncytial virus (RSV) observed during two winter seasons (weeks 40-20) and inter-seasonal periods (weeks 21-39) during the pandemic between October 2020 and September 2022.<h4>Methods</h4>Using data submitted ...[more]

PMID: 38025589

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Project description:ImportanceRespiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) and infant hospitalization worldwide.ObjectiveTo evaluate the characteristics and outcomes of RSV-related critical illness in US infants during peak 2022 RSV transmission.Design, setting, and participantsThis cross-sectional study used a public health prospective surveillance registry in 39 pediatric hospitals across 27 US states. Participants were infants admitted for 24 or more hours between October 17 and December 16, 2022, to a unit providing intensive care due to laboratory-confirmed RSV infection.ExposureRespiratory syncytial virus.Main outcomes and measuresData were captured on demographics, clinical characteristics, signs and symptoms, laboratory values, severity measures, and clinical outcomes, including receipt of noninvasive respiratory support, invasive mechanical ventilation, vasopressors or extracorporeal membrane oxygenation, and death. Mixed-effects multivariable log-binomial regression models were used to assess associations between intubation status and demographic factors, gestational age, and underlying conditions, including hospital as a random effect to account for between-site heterogeneity.ResultsThe first 15 to 20 consecutive eligible infants from each site were included for a target sample size of 600. Among the 600 infants, the median (IQR) age was 2.6 (1.4-6.0) months; 361 (60.2%) were male, 169 (28.9%) were born prematurely, and 487 (81.2%) had no underlying medical conditions. Primary reasons for admission included LRTI (594 infants [99.0%]) and apnea or bradycardia (77 infants [12.8%]). Overall, 143 infants (23.8%) received invasive mechanical ventilation (median [IQR], 6.0 [4.0-10.0] days). The highest level of respiratory support for nonintubated infants was high-flow nasal cannula (243 infants [40.5%]), followed by bilevel positive airway pressure (150 infants [25.0%]) and continuous positive airway pressure (52 infants [8.7%]). Infants younger than 3 months, those born prematurely (gestational age <37 weeks), or those publicly insured were at higher risk for intubation. Four infants (0.7%) received extracorporeal membrane oxygenation, and 2 died. The median (IQR) length of hospitalization for survivors was 5 (4-10) days.Conclusions and relevanceIn this cross-sectional study, most US infants who required intensive care for RSV LRTIs were young, healthy, and born at term. These findings highlight the need for RSV preventive interventions targeting all infants to reduce the burden of severe RSV illness.

Dataset Information

Seasonal and inter-seasonal RSV activity in the European Region during the COVID-19 pandemic from autumn 2020 to summer 2022.

Background

Methods

Results

Conclusion

Publications

Seasonal and inter-seasonal RSV activity in the European Region during the COVID-19 pandemic from autumn 2020 to summer 2022.

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